GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs10935120 | 1 | rs9989967 | chr3:134238964 | ANAPC13 | chr3:134196547-134204865:- | 0.38 | 4.37 | 2.26E-5 | Height |
| UCEC | cis | rs10935120 | 1 | rs9990351 | chr3:134239191 | ANAPC13 | chr3:134196547-134204865:- | -0.38 | -4.42 | 1.89E-5 | Height |
| UCS | cis | rs9894429 | 1 | rs11652797 | chr17:79574124 | TSPAN10 | chr17:79609349-79615778:+ | 0.79 | 6.33 | 4.22E-7 | Eye color traits |
| UCS | cis | rs4869313 | 1 | rs4869313 | chr5:96223880 | ERAP2 | chr5:96211644-96255398:+ | -0.85 | -9.14 | 1.96E-10 | Pediatric autoimmune diseases |
| UVM | cis | rs4974559 | 1 | rs10006789 | chr4:1330333 | CRIPAK | chr4:1385340-1389782:+ | 0.81 | 4.63 | 2.27E-5 | Systolic blood pressure |
| UVM | cis | rs2273 | 1 | rs10008757 | chr4:76903036 | NAAA | chr4:76831809-76862166:- | -0.44 | -4.99 | 6.33E-6 | Longevity |
| UVM | cis | rs1003719 | 1 | rs1003719 | chr21:38491095 | PIGP | chr21:38437664-38445458:- | -0.63 | -4.93 | 8.02E-6 | Eye color traits |
| UVM | cis | rs10461617 | 1 | rs10051747 | chr5:56083289 | C5orf35 | chr5:56205103-56213010:+ | 1.05 | 6.59 | 1.79E-8 | Type 2 diabetes |
| UVM | cis | rs8135828 | 1 | rs1006396 | chr22:30017000 | CABP7 | chr22:30116344-30127818:+ | 1.03 | 6.84 | 6.87E-9 | Lipid traits |
| UVM | cis | rs2239557 | 1 | rs10140433 | chr14:74659989 | LIN52 | chr14:74551656-74667117:+ | -0.44 | -5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs2239557 | 1 | rs10144220 | chr14:74647904 | LIN52 | chr14:74551656-74667117:+ | -0.44 | -5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs2239557 | 1 | rs10150201 | chr14:74649157 | LIN52 | chr14:74551656-74667117:+ | -0.44 | -5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs4660306 | 1 | rs10157597 | chr1:45990278 | CCDC163P | chr1:45960581-45965646:- | -0.76 | -7.95 | 1.07E-10 | Homocysteine levels |
| UVM | cis | rs13014235 | 1 | rs10178982 | chr2:202227640 | ALS2CR12 | chr2:202153148-202222101:- | -0.46 | -4.69 | 1.82E-5 | Basal cell carcinoma |
| UVM | cis | rs13014235 | 1 | rs10206231 | chr2:202229225 | ALS2CR12 | chr2:202153148-202222101:- | -0.46 | -4.69 | 1.82E-5 | Basal cell carcinoma |